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Given the FDA's April 2026 proposal with a comment period closing June 29, 2026, this a real question for anyone starting a multi-month compounded GLP-1 program right now

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Since programs using semaglutide, tirzepatide, or phentermine are considered elective, most insurance plans do not provide coverage

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In addition to the results from SURPASS 4, which was designed to provide preliminary evidence for the cardiovascular safety of tirzepatide, a separate analysis pooling all the clinical trials with tirzepatide was used to generate a pre-specified estimate of cardiovascular events [20] (Table 1)

Preclinical studies in mice demonstrate reduced atherosclerotic plaque progression and increased plaque stability