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Glutathione helps to combat oxidative damage

Ferroptosis is an iron-dependent process driven by lipid peroxidation, governed by the inactivation of glutathione peroxidase 4 (GPX4) and dysregulation of iron metabolism (such as SLC7A11/GSH axis, NRF2-FTH1 pathway), with morphological features including mitochondrial shrinkage and membrane lipid peroxidation independent of caspase activation (115, 116)

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Longer use may blunt responsiveness due to IGF-1 receptor downregulation

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