Ipamorelin vs GHRP-2 and GHRP-6 GHRP Family Side-by-Side Feature Receptor Ipamorelin GHS-R1a GHRP-2 GHS-R1a GHRP-6 GHS-R1a Feature Half-life Ipamorelin ~2 hours GHRP-2 ~25-30 minutes GHRP-6 ~20-30 minutes Feature Dosing Ipamorelin 1-3x daily (SubQ) GHRP-2 2-3x daily (SubQ) GHRP-6 2-3x daily (SubQ) Feature Standard dose Ipamorelin 100-300 mcg GHRP-2 100-300 mcg GHRP-6 100-300 mcg Feature Cortisol effect Ipamorelin None at standard doses GHRP-2 Yes GHRP-6 Yes Feature Prolactin effect Ipamorelin None GHRP-2 Moderate GHRP-6 Minimal Feature Appetite effect Ipamorelin Mild GHRP-2 Moderate GHRP-6 Strong Feature FDA status Ipamorelin Not approved GHRP-2 Not approved GHRP-6 Not approved All three target the same receptor
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PMID: 30 KoldeR
This is a major feat in the weight management space, as synthetic GLP-1 medications have been shown to decrease muscle mass, potentially leading to long-term issues with mobility and bone health
However, a retrospective cohort study of electronic health records involving 240,618 patients with overweight or obesity prescribed semaglutide or non-GLP-1 receptor agonist antiobesity medications, and 1,589,855 patients with type 2 diabetes prescribed semaglutide or other hypoglycaemic agents, found a lower risk of suicidal ideation in patients prescribed semaglutide regardless of prior psychiatric history
They help: remove damaged cells regulate inflammation repair tissue In endometriosis, however, macrophages often behave differently