The sterol biosynthesis pathway depicted in Figure 2 highlights how alterations at key enzymatic steps can lead to the production of alternative sterols that diminish AmB efficacy
Interestingly, like BETP, compound 2 interacts with cysteine 347 6.36 via covalent modification at the cytoplasmic side of GLP-1R, consistent with our previous observation that an intact ECD is required for the activity of BETP and compound 2 (ref
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Dietary protein , particularly whey protein, can stimulate GLP-1 and peptide YY (PYY) release, contributing to appetite regulation and improved post-meal blood sugar control
Nutr Metab and Cardiovasc Dis