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That lower pH is necessary for certain research compounds that simply won't dissolve at neutral pH

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However, most of the work on this final rule with comment period was not completed in accordance with our usual schedule for final CY OPPS/ASC payment rules, which aims for an issuance date of November 1, followed by an effective date of January 1, to ensure that the policies are effective at the start of the calendar year to which they apply

The same principle likely applies here

For these reasons we believe that the number of past commenters would be a fair estimate of the number of reviewers of this rule