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The bioavailability of levocarnitine is less than 20%, but acetlycarnitine and propionlycarnitine may be higher

Cytosolic Ca 2+ entering the mitochondrial matrix through the mitochondrial Ca 2+ uniporter (MCU) stimulates OXPHOS by activating pyruvate dehydrogenase phosphatase, which in turn, increases the activity of pyruvate dehydrogenase complex [21]

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Based on the abovementioned clinical issues, it is imperative to investigate the molecular mechanism underlying the onset and progression of CKD to identify novel therapeutic targets

[18] showed that intravenous infusion of GLP-1 for 48 hours in animal models with induced dilated cardiomyopathy significantly improved LV contractility, stroke volume, and cardiac output