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Since GLP-1s are relatively new drugs, their long-term side effects are unknown

One diverse set of examples is the heme proteins, which consist of a porphyrin ring coordinated to iron

doi:10.1186/1742-2094-5-19 62

That slow decline gets rolling quite early, when people are in their twenties, but it really speeds up after 60

At the conclusion of the STEP 1 trial, the average weight loss among the 1,961 participants averaged 14.9% of their initial body weight.[2] For example, if a participant started at 260 pounds and lost 14.9% of their body weight, they would have lost 38.7 pounds