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Major limitations include the lack of large human clinical trials, limited pharmacokinetic data, sparse toxicology research, and a shortage of direct combination studies

In a high-dose melphalan setting, palifermin compared with placebo had no effect on oral mucositis or related patients burden

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It is important to have realistic expectations and to understand that such products are not a substitute for sun protection or medical treatment of pigmentary disorders

A previous study reported significantly increased lipid peroxidation (measured by 4-HNE and MDA) in the synovial cells of OA than in RA patients and controls [46]

doi: 10.3389/fimmu.2018.02122 25 ChenC