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Produced via solid-phase peptide synthesis with subsequent copper complexation, GHK-Cu is associated with matrix metalloproteinase regulation and growth factor signalling pathways

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This provides an alternative fuel source for the brain and may contribute to appetite suppression

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Together, these signaling pathways elucidate the multifaceted roles of metformin in glioma treatment, highlighting its potential as a therapeutic agent that not only induces cell death but also modifies key regulatory mechanisms within the cancer cells