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Estrogens and antiestrogens activate hPXR

The generic must demonstrate that its product is pharmaceutically equivalent (same active ingredient, dosage form, route of administration, and strength) and bioequivalent (no clinically significant difference in rate and extent of absorption) to the RLD

Phase I and Phase II estrogen metabolism: In the liver, the CYP450 enzymes can metabolize estrogen

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Niagen, on the other hand, undergoes rigorous testing, and has an extensive research program behind it. Niagen is a patented form of NR (and we also own the patents), so its far more reliable in terms of safety, potency, and consistency