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They are not associated with cardiovascular protection beyond glucose lowering, so they are typically chosen when GLP-1 agonists or SGLT2 inhibitors are unsuitable
Ye XF, Wang WY, Wang XY, Huang QF, Li Y, Wang JG
2022 Nov;27(11):444652
doi: 10.1126/sciadv.ads3506 69 KimDHKangYNJinJParkMKimDYoonGet al
The formation of 8-hydroxy guanosine leads to mutation in DNA (46)
