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At high concentrations, QUE catalyzes the reduction of metal ions, generating ROS and causing oxidative damage to DNA and other cellular components (52)

(3) The estimated savings over 5 years was between $2.8 million and $17.6 million (Cdn)

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These findings suggest that targeting SHANK3 mutations could be a promising strategy for addressing the cellular deficits underlying some forms of ASD

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