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[DOI] [PMC free article] [PubMed] 69.Pratley R, Amod A, Hoff ST, Kadowaki T, Lingvay I, Nauck M, Pedersen KB, Saugstrup T, Meier JJ, PIONEER 4 investigators

Lipid overload has been suggested to cause the loss or downregulation of autophagy, leading to fat accumulation, mitochondrial disorders, inflammation, and decreased pancreatic -cell quality, all of which may eventually lead to IR and T2DM 30

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Furthermore, schisandrin A counteracts LPS-induced suppression of autophagy by activating AMP-activated protein kinase- Unc-51-like autophagy activating kinase 1 (AMPK-ULK1) signaling and inhibiting mammalian target of rapamycin (mTOR) phosphorylation, contributing to its anti-inflammatory effects [35]

Furthermore, ongoing studies are exploring the long-term effects of Ozempic, including its impact on weight management and overall metabolic health, which could provide even more insights into its benefits for those living with diabetes