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Later, this definition was extended to include essentially similar protective effects outside the gastrointestinal tract involving the lesions of different organs (cytoprotection-organoprotection)

J Appl Toxicol 21:6973 Hur JM, Hyun MS, Lim SY, Lee WY, Kim D (2009) The combination of berberine and irradiation enhances anti-cancer effects via activation of p38 MAPK pathway and ROS generation in human hepatoma cells

Medicine 98 (45), e17824

In addition, some cultures use glutathione as a skin brightener to lower melanin levels, which also helps fade aging spots

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