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JQ1 therapy or BRD4 gene knockout can down-regulate ferroptosis regulators including SLC7A11 (Sui et al., 2019)

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10.1007/s10482-021-01546-2 37 IwamotoK.ShiraiwaY

This routes limitation is related to the small dose that can be administered, which implies the need to design and formulate a drug with a high loading capacity [16], making the route effective only for very potent drugs [6]

Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects