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IGF-1 levels and total SHIM score correlate significantly ( r =0.31, P =0.02), as do IGF-1 levels and all individual SHIM question scores, and IGF-1 levels and the sexual domain of the EPIC questionnaire ( r =0.30, P =0.02)

The biggest drug response was found in these patients, while participants that did not show any peripheral insulin desensitization showed no drug effect [189]

Statistical analysis For animal studies, sample sizes were calculated based on a power analysis assuming that a body weight difference of 5 g between the treatment groups can be captured with a power of 75% when using a two-sided, two-tailed statistical test under the assumption of a s.d

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