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Back UK Government (14 Oct 2014) Press Release: Landmark collaboration with largest pharmaceutical company

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The tirzepatide before and after data shows similar threshold effects at the 15% mark, reinforcing that this is a physiologically meaningful breakpoint across compound classes

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The researchers noted that glucagon and GLP-1 can produce positive chronotropic and positive inotropic effects on the heart, but analyzed that the magnitude of the increase was similar to levels reported for existing GLP-1 receptor agonists