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Functionally, in severe cyclophosphamide hemorrhagic cystitis lesions (i.e., urothelial necrosis, vesical edema, erosion, hemorrhage, inflammation, and ulceration, increased bladder weight), the increased leak point pressure was reversed to the values noted in the normal rats [91]

Another reason why Nrf2 can serve an oncogenic function is related to the promotion of HO-1 expression

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De Santis S, Cavalcanti E, Mastronardi M, Jirillo E, Chieppa M