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Chronic SASP creates a pro-inflammatory environment, disrupts tissue homeostasis, promotes dysfunction and fibrosis, and may even drive cancer progression [62]

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The dorsal putamen was selected as the center of the volume of interest due to its relatively homogenous mix of neurons and astrocytes, and suitable distance from bone and other regions that could compromise signal quality

Ionization was achieved using electrospray in the positive ionization mode with an ion spray voltage of 4 kV

However, this production begins to decline as we enter our late 20s and 30s, often exacerbated by environmental stressors