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In a 48-week clinical trial, higher doses consistently led to greater average weight loss: Weight loss by dose (48-week clinical trial) In this trial, at the highest dose (12 mg), people lost an average 24% of their starting weight on average
Ongoing phase 3 clinical trials are testing the medication for weight management, osteoarthritis, NAFLD, cardiovascular risk reduction, type 2 diabetes, and moderate to severe obstructive sleep apnea in obese and overweight patients
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The average decline in HbA1c among treatment groups was 1.7 to 1.9 percentage points, more than double the placebo groups 0.8 percentage-point decrease
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