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Cause #3: Low Vitamin D Vitamin D is essential for RFC-mediated folate transportthe backup pathway that high-dose Leucovorin depends on

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Marton A, Saffari SE, Rauh M, Sun RN, Nagel AM, Linz P, et al

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Groups were assigned as MTX-vehicle, NTZ-100, and NTZ-200 groups (at 100 and 200 mg/kg/day, gavage, respectively), N-acetyl cysteine (NAC) group (500 mg/kg), and 4-phenyl butyric acid (4-PBA) group (150 mg/kg, i.p)

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