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For comparison there is a recent large retrospective cohort study (2) that uses deidentified data on patients from 66 different health care organizations

[DOI] [PubMed] [Google Scholar] 155.Sappington D.R., Siegel E.R., Hiatt G., Desai A., Penney R.B., Jamshidi-Parsian A., Griffin R.J., Boysen G

Lindstedt G, Lundberg PA, Lapidus L, Lundgren H, Bengtsson C, Bjorntorp P

And the internet is full of conflicting advice, with some people saying a little warmth is fine and others insisting you should never use a medication that left the cold chain

These criteria are not rigid cutoffs but starting points for clinical conversation

[DOI] [PubMed] [Google Scholar] 57.Rani B., Silva-Marques B., Leurs R., Passani M.B., Blandina P., Provensi G