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This therapy also showed massive improvements in comorbidities like knee pain and inflammatory cardiovascular markers such as high-sensitivity C-reactive protein

[7] (This interaction is not significant when levodopa is combined with carbidopa, as in standard carbidopa/levodopa therapy, because carbidopa prevents peripheral levodopa breakdown.) Another notable interaction involves the chemotherapeutic agent altretamine: coadministration of pyridoxine can decrease altretamines effectiveness and is generally advised against unless specifically directed

Dehvan F, Baghi V, Lotfi A, Ghanei Gheshlagh R

& Rathmell, J

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Animal studies indicate dose-dependent effects, with toxic doses possibly affecting copper metabolism or interacting with embryonic development in hypersensitive models, warranting caution during pregnancy