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The clinical evidence, as reviewed above, is clear: tirzepatide is the superior medication for weight loss in adults without type two diabetes

Tirzepatide primarily reduces fat gain through appetite suppression and improved nutrient partitioning

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Quesada, I., Tudur, E., Ripoll, C

Cytokine Production: GLP-1R activation directly inhibits the production of pro-inflammatory cytokines (TNF-, IL-1, IL-6) and increases anti-inflammatory mediators like adiponectin

Alongside its use for overweight and obesity, studies of the drug focused on treating non-cirrhotic metabolic dysfunction-associated steatohepatitis (MASH), a condition where fat builds up in the liver