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Differences between two groups were evaluated using t-tests, and comparisons among multiple groups were performed using one-way analysis of variance with Bonferroni post hoc test

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GHK-Cu occurs naturally in the human body and decreases with age

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Inhibition of -glutamyl transpeptidase (GGT) impaired the ability of GSH or cell-permeable GSH to restore mTORC1 signaling and the ISR, suggesting that the capacity of GSH to release cysteine, but not GSH per se, regulated the signaling networks

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