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This reduction in swim speed is consistently observed in both F0 and F1 adult transgenic fish carrying LMNA (E358K) and LMNA (R453W) variants, mirroring the established pathogenic roles of these variants in individuals with LMNA -related CMD and EDMD2

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For weight management, NICE has approved: Semaglutide 2.4 mg (TA875) for adults with a BMI of 35 kg/m (or 32.5 kg/m for people from South Asian, Chinese, other Asian, Middle Eastern, Black African, or African-Caribbean backgrounds) with at least one weight-related comorbidity, and for some people with BMI 30-34.9 kg/m meeting specific criteria