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found that increased GPx1 levels significantly increased the resistance of breast cancer T47D cells to doxorubicin partially by interfering with the activation of the sphingomyelin-ceramide pathway [85]

In contrast to saline-injected WT mice, saline-injected Gpx1 KO mice showed low GSH/GSSG ratio, increased hydrogen peroxide and high MDA level in the liver and spleen (Figure 6)

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PMID: 35457222

This combination is particularly interesting for aging-related tissue deterioration, where both mitochondrial dysfunction and impaired repair signaling contribute to declining tissue health

Cellular senescence and inflammaging in age-related diseases