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The article says major diabetes trials prioritize monotherapy or the stepwise addition of non-incretin agents over dual-incretin combinations, and it frames the cost and complexity of doubling up on incretins as unjustified by the clinical gain

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500 kcal during an ad libitum lunch test after 3 weeks of treatment [67]

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For a 70kg person at the high end: 70 x 40 = 2,800mg per day

Most people will experience an average weight loss of 3.8%