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Semaglutide GLP-1 is a GLP-1 receptor agonist, while tirzepatide is a dual GIP/GLP-1 receptor agonist, offering potentially enhanced weight loss benefits for some individuals

Fluorescence was detected by confocal laser scanning microscopy (CLSM) (Zeiss, LSM800, Germany)

This classification process included subsequent discussions with NAMNK, YSK, and FA to address and resolve any discrepancies in the category

Similar observations have been made in other studies 34, 35 and indicate that the initial large reduction in blood pressure is a transient acute response to hypocaloric states and large acute weight loss

doi:10.1136/bmjopen-2018-023830 173

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