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Diabetes 56 , 984991 (2007)

Conclusion In summary, we report a novel ECM-dependent FAK/MEK/ERK/MITF axis that controls the plasticity of MCs in response to interactions with their environment

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They haven't, and they won't because it's not true, he said

Mantovani et al., 2021)

Even in the hypertension literature, it was ignored as a first line option in ALLHAT (Furberg et al, JAMA 2002) despite being approved in 1960 by the FDA at the same time as chlorthalidone