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Medicine 96 , e7293 (2017)

Reduced systemic inflammation Modulates NF-B signaling to lower inflammatory cytokine activity

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Unfortunately, despite its high prevalence, a large number of MASLD cases remain undiagnosed, often leading to a diagnosis of cryptogenic cirrhosis, where MASH is the underlying condition once other etiological factors for chronic liver disease, such as alcohol abuse, viral hepatitis, autoimmune disorders, and other metabolic diseases, have been excluded [23]

Also, all other mutations found at this position in high replicator ReEDs presented a hydrophobic amino acid (P2209A/V/I) and enhanced RF to a various extent, but less efficiently than P2209L (Fig