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The use of GSH precursors like N-acetyl cysteine, enhancers of nuclear factor erythroid 2-related factor 2 (Nrf2) like sulforaphane, melatonin, and many more molecules involved in antioxidant defense were proposed as supplementation of other idiopathic pulmonary fibrosis therapies (130)

Metabolism It is commonly accepted that immune cells undergo metabolic reprogramming to sustain dysfunction linked to neurodegeneration in PD [112, 113], whereby cellular metabolic alterations disrupt immune cell energy homeostasis, leading to aberrant inflammation in both the brain and the peripheral nervous system

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doi: 10.1146/annurev.pharmtox.38.1.321

SB203581, SP600125, and PD0325901 were purchased from Selleck Chemicals (Houston, TX, United States)