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If a previously effective concentration suddenly yields poor results, and you can rule out other variables, peptide degradation is a likely suspect

10.1016/j.jep.2024.118054 125 YanL

Conceptually, its practical significance has been ascribed to its particular role in the Selyes stress response [3,7,8], as well as to its resolving of activities of the braingut and gutbrain axes [7,12]