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Studies have observed decreased cyclooxygenase-2 (COX-2) gene expression, reduced myeloperoxidase activity, and lower levels of pro-inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-)

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RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state

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