Optogenetic versions of these so-called superactive PLDs (superPLDs) were able to produce significantly higher amounts of PA in cells upon demand, enabling perturbation of a wider array of PA-dependent signaling pathways (e.g., Hippo, mTOR, and AMPK)
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Then 4-phosphopantothenic acid decarboxylase removes CO 2 to produce 4-phosphopantetheine