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doi: 10.1073/pnas.93.23.13316 90 MasakiTYoshimatsuHChibaSWatanabeTSakataT

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Highlights from study findings include: 751 individuals participated in the study The mean percent change in weight at week 72 was -20.2% for those taking tirzepatide and -13.7% for those taking semaglutide The most common side effects were gastrointestinal A 2025 real-world study of over 2,300 patients treated at an academic obesity clinic also showed meaningful weight loss, especially among those who stayed on therapy for at least a year

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