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The findings also support our previous observation that Hsp70 knockdown reduced Artemia nauplius tolerance to bacterial pathogens, which could be explained by the fact that loss of Hsp70 downregulated several Toll receptor genes ( NT1 and Spaetzle ) and reduced the integrity of the exoskeleton, allowing pathogens to enter and cause infection, ultimately resulting in mortality

Wolff V, Laurer V, Rouyer O, Sellel F, Meyer N, Raul JS, et al