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Abstract Interleukin-23 (IL-23) and Tumor Necrosis Factor-alpha (TNF-) are key pro-inflammatory cytokines that regulate the progression of inflammation

NO can react with the cysteine of GSH to form GSNO that may be considered an endogenous NO reservoir, which can release it when it reacts with Cu + or with denitrosylating enzymes such as Trx and GSNO reductase (Sengupta and Holmgren, 2013)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Lee S.-H., Seo S.H., Lee D.-H., Pi L.-Q., Lee W.-S., Choi K.-Y

The path forward For 5-amino-1mq to move from research compound to established therapy, human clinical trials are needed

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