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Thats exactly why so many in-vitro experiments use fibroblast cultures as their starting point when studying this compound

Peptide Integrity and Ingredient Compatibility. 2024

Saleh, D

Life Sci 61:PL 361371

There were 23 clinical studies published between 2020 and 2025 that support collagen as a nutraceutical treatment that showed improvement in various skin attributes, but investigations are lacking on collagens effectiveness on scalp, hair, and nail health, which warrants further examination

If so, oxidative stress-induced changes in DHA could be a major factor contributing to accelerated activity in vivo , at least in some compartments