gip and glp-1 Major physiological roles of GIP. Tirzepatide is acting as an Designing a dual GLP-1R/GIPR agonist

It can push stem or progenitor cells towards repair phenotypes and it advances regeneration-specific cell cycle genes

Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass

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In conclusion, our study provides novel therapeutic strategies for the treatment of KOA

They are not metabolised by the same enzymes, do not compete for the same receptors, and have no known contraindications at standard supplemental doses