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Moreover, lipid peroxidation-driven plasma membrane rupture will accelerate KRAS-mediated pancreatic tumorigenesis by promoting DAMPs release, resulting in the activation of inflammatory pathways and polarization of macrophages for tumor growth [234]

Gclc f/f mice (hereafter described as Gclc WT) were also treated with tamoxifen to control for potential confounding effects associated with tamoxifen treatment

Free radical derivatives formed from cyclooxygenase-catalyzed dihomo-gamma-linolenic acid peroxidation can attenuate colon cancer cell growth and enhance 5-fluorouracils cytotoxicity

Methods The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (Page et al

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All curcuminoid compounds were found to inhibit gene expression in a manner that is dose-related