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Metabolism was halted at specific time intervals by precipitating proteins with acetonitrile and acetic acid

The parent compound, Nle-AngIV, demonstrated an exceedingly short half-life of less than 2 minutes

Gene expression analysis indicated that these suboptimal results were likely due to lower endogenous Nodal signaling and elevated BMP signal activities [1]

After a 30-minute incubation on ice, blood samples were collected at various time points post-intravenous 10 mg/kg dose or intraperitoneal 20 mg/kg dose administration of Dihexa dissolved in 75% DMSO

Taking 1 mL working solution as an example, add 100 L DMSO stock solution ( 25.0 mg/mL ) to 400 L PEG300 , and mix evenly

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