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Mitochondria are also involved in key cellular functions such as Ca 2 + homeostasis, heme biosynthesis, nutrient metabolism (Renault and Chipuk, 2013)

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In an open uncontrolled trial in 20 men with idiopathic infertility and a low testosterone-to-estrogen ratio, three months of treatment with letrozole resulted in improved sperm motility and morphology, reduced sperm DNA fragmentation, increased testosterone-to-estrogen ratio, and four spontaneous pregnancies

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Fu Y, Li S, Nie J, Yan D, Zhang B, Hao X