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The regular vitamin D metabolic profiles illustrated with either wild-type mouse VDR or VDR null mice transgenic for the wild-type human VDR, but not the ligand binding-defective form of the protein, this suggests the essential roles of VDR on VD metabolism 25

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(6) Rapid tachyphylaxis: Continued tyramine exposure depletes releasable NE stores and replaces NE with pharmacologically weak false neurotransmitter stores, leading to diminished responsiveness despite ongoing tyramine presence

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Niu SW, Chang KT, Ta A, Chang YH, Kuo IC, Hung CC, et al

Devices to overcome the buccal mucosal barrier to administer therapeutic peptides