A later phase 3b trial of the higher 7.2 mg dose, STEP UP, reported mean bodyweight change of 18.7% at 72 weeks versus 15.6% at 2.4 mg and 3.9% with placebo
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64% say theyre more mindful with food purchases, and many are budgeting or tracking finances since starting GLP-1s
Recent clinical data shows these medications can produce meaningful metabolic changes across various body weight categories, raising important questions about appropriate patient selection and expected outcomes
When histamine accumulates faster than the body can clear it, symptoms develop, and for women with lipoedema, those symptoms can significantly worsen the inflammatory load they are already managing
If burping persists beyond that window, it is unlikely to resolve spontaneously and needs active management