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According to the SmPC, the following frequencies have been observed: Nausea (very common: may affect more than 1 in 10 people) Diarrhoea (very common: may affect more than 1 in 10 people) Vomiting (very common: may affect more than 1 in 10 people) Constipation (common: may affect up to 1 in 10 people) Abdominal pain and discomfort (common: may affect up to 1 in 10 people) Decreased appetite (very common: may affect more than 1 in 10 people) These effects typically diminish over time as the body adjusts to the medication, and gradual dose escalation helps minimise their severity

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Using a chronic obstructive pulmonary disease (COPD) mouse model, researchers investigated the relationship between GLP-1 and ANP through genetic GLP-1 receptor (GLP-1R) knockout, pharmaceutical GLP-1R blockade, and exogenous GLP-1 administration

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