Both of those effects have downstream consequences for hydration that most patients arent warned about
These often improve as the body adjusts, but some people may experience persistent gastrointestinal discomfort
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At a normal therapeutic dose, acetaminophen is primarily metabolized by the liver to sulfate and glucuronide conjugates, while a SMALL amount is metabolized by CYP2E1 to a highly reactive intermediate, N-acetyl-p-benzoquinone imine (NAPQI)
For the higher doses (8 mg and 12 mg), additional slower titration cohorts were included to further characterise tolerability
By the end of the trial period, average results showed: Those on a 4 mg dose lost 47.2 pounds (lb), or about 19 percent of their starting body weight