This transporter facilitates the influx of cystine into the cell, where it is reduced to cysteine, which then participates in the synthesis of glutathione (GSH) through a reaction with GSH [91]
In the next step, a second equivalent of GSH reacts with the glutathionylated intermediate to form the stable product GSSG, and this allows the release of the reduced selenium or cystine for the next catalytic cycle (see Figure 4 for an example of GPX4 oxidoreductase mechanism)
A few clinic-based reports and testimonials suggest subjective improvement in energy or appetite control, but those are susceptible to placebo effects, co-interventions (sleep, hydration, counseling), and selection bias
Endometriotic stromal and epithelial samples display a significant increase in levels of SOD and GSH
Neurology 83, 21832187
The scientific community remains eager to see future studies that can definitively establish its role in human health and healing