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Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X et al (2016) Ferroptosis: process and function
doi: 10.2147/CCID.S68424 [DOI] [PMC free article] [PubMed] [Google Scholar] 6.Arjinpathana N, Asawanonda P
There are 2 primary mechanisms: Ascorbic Acid (Ascorbate) uptake using sodium-dependent vitamin C transporter (SVCT) 1 or 2 Ascorbic Acid (Ascorbate) Recycling Ascorbic Acid (Ascorbate) transport using sodium-dependent vitamin C transporter (SVCT) 1 or 2 As shown below, SVCT 1 and SVCT 2 transport ascorbic acid or ascorbate into the cell against the concentration gradient (represented by the orange wedge in the figure below)
By reducing exercise-induced oxidative stress, improving mitochondrial redox balance, and supporting protein synthesis, amino acids such as glycine and NAC could amplify the benefits of physical training
The capability of Sp to replenish reduced glutathione levels was further tested in neuronal cells exposed to MPP + , the toxic bioactivation product of MPTP known to induce Parkinsonian phenotype in animal models 1
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