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Furthermore, T cells are divided into CD4 and CD8 subsets, while T cells and NKT cells represent distinct subpopulations [138]

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It seems that the STAT3-induced expansion of immunosuppressive cells inhibits the surveillance of senescent cells which enhances their accumulation within tissues with aging [122]

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therefore, calcium supplementation is not currently prescribed for the prevention or treatment of metformin-induced vitamin B 12 deficiency (145)